反应详情

A solution of 4-acetylaminomethylpyridine (22.40 g) and ethyl iodide (17.9 ml) in acetone (300 ml) was heated under reflux for 24 hours and then the solvent was evaporated in vacuo. The residue was washed with a mixture of n-hexane, ethyl acetate and ethanol to give very hygroscopic 4-acetylaminomethyl-1-ethylpyridinium iodide (42.18 g), which was used without further purification.

1. temperatureunder reflux for 24 hours
2. customthe solvent was evaporated in vacuo
3. washThe residue was washed with a mixture of n-hexane, ethyl acetate and ethanol