反应详情

A solution of 32 g (313 mmol) of acetic anhydride in 200 ml of benzene is added, drop by drop, to a suspension, stirred and heated to reflux, of 40 g (290 mmol) of potassium carbonate and 30 g (285 mmol) of aminoacetaldehyde dimethyl acetal in 200 ml of benzene. Reflux is maintained for 30 min., then the mixture is cooled and filtered, the precipitate is washed with benzene, the filtrate is evaporated and the residual oil is treated with vegetable charcoal in 300 ml of diethyl ether. After filtration and evaporation, 36.8 g (250 mmol) of product are obtained. n25D =1.4450.

1. temperatureheated
2. temperatureReflux
3. temperatureis maintained for 30 min.
4. temperaturethe mixture is cooled
5. filtrationfiltered
6. washthe precipitate is washed with benzene
7. customthe filtrate is evaporated
8. additionthe residual oil is treated with vegetable charcoal in 300 ml of diethyl ether
9. customare obtained