p-Toluenesulfonic acid → N-[5-(6-Methoxynaphthalen-1-yl)-1,3-dioxan-2-yl]-methylacetamide

HRID 1613336Notes

Reaction equation

HRID 1613336 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH:13]([CH2:16][OH:17])[CH2:14][OH:15])=[CH:8][CH:7]=[CH:6]2.[C:18]1(C)C=CC(S(O)(=O)=O)=CC=1.COC(OC)[CH2:32][NH:33][C:34](=[O:36])[CH3:35]>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([CH:13]1[CH2:16][O:17][CH:32]([NH:33][C:34](=[O:36])[CH2:35][CH3:18])[O:15][CH2:14]1)=[CH:8][CH:7]=[CH:6]2

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 15289457N-(2,2-Dimethoxyethyl)acetamideHCID 153458012-(6-Methoxynaphthalen-1-YL)propane-1,3-diol

Product 1

HCID 67859839N-[5-(6-Methoxynaphthalen-1-yl)-1,3-dioxan-2-yl]-methylacetamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2.3 g (10 mmol) of 2-(6-methoxynaphthalen-1-yl)propane-1,3-diol, 0.45 g of paratoluenesulphonic acid and 1.6 g (11 mmol) of N-(2,2-dimethoxyethyl)acetamide are introduced into a flask containing 200 ml of benzene.

Sources & evidence

ORD record
ord-8c5558adc9ab4f3c8141be9bf3171969
Source dataset
uspto-grants-1993_03
Patent number
US05192797

Reaction notes

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