Propofol → 1-(2,6-Diisopropylphenyloxy)-2-propanol

HRID 1613549Notes

Reaction equation

HRID 1613549 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].[CH2:14]1[O:17][CH:15]1[CH3:16].C(C1C=CC=CC=1O)(C)(C)C.C1OC1CC>>[CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5]=1[O:13][CH2:14][CH:15]([OH:17])[CH3:16])([CH3:12])[CH3:11]

Participants

5

Reactant 4

HCID 4943PropofolHCID 6378Propylene OxideHCID 69232-Tert-ButylphenolHCID 78341,2-Epoxybutane

Product 1

HCID 197740591-(2,6-Diisopropylphenyloxy)-2-propanolYield 90%

Procedure

The synthesis was carried out in the same manner as described in Example 3a, except that 50.0 g (0.28 mol) of 2,6-diisopropylphenol and 22.0 g (0.31 mol) of propyleneoxide were used instead of 350 g (2.33 mol) of 2-tert-butylphenol and 176 g (2.45 mol) of 1,2-butyleneoxide. 59.5 g of 1-(2,6-diisopropylphenyloxy)-2-propanol (bp. 138° C./5 mm Hg) were obtained in a 90% yield.

Sources & evidence

ORD record
ord-57888496197f4886bea4af07b7853f64
Source dataset
uspto-grants-1993_03
Patent number
US05194423

Reaction notes

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