Hydrochloric Acid → 4-(Benzodioxan-5-yl)-1-[2-(ind-1-en-1-yl)-acetyl]-piperazine

HRID 1613571Notes

Reaction equation

HRID 1613571 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[CH2:21][CH:20]=4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1.Cl.C1(CC(O)=[O:40])C2C(=CC=CC=2)CC=1>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:12][CH2:13][N:14]([C:17](=[O:40])[CH2:18][C:19]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[CH2:21][CH:20]=4)[CH2:15][CH2:16]3)[C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 30140221H-Indene-3-acetic acidHCID 104513124-(Benzodioxan-5-yl)-1-[2-(ind-1-en-1-yl)-ethyl]-piperazine

Product 1

HCID 117402504-(Benzodioxan-5-yl)-1-[2-(ind-1-en-1-yl)-acetyl]-piperazineYield 30%

Procedure

4-(benzodioxan-5-yl)-1-[2-(ind-1-en-1-yl)-ethyl]-piperazine and its hydrochloride, m.p. (K): 254°-256° C., by reduction of 4-(benzodioxan-5-yl)-1-[2-(ind-1-en-1-yl)-acetyl]-piperazine (yield: 30%), which was itself prepared in a yield of 66% from 2-(ind-1-en-1-yl)acetic acid [m.p. (K): 92°-94° C.]and N-(benzodioxan-5-yl)piperazine.

Workup

  1. custom254°-256° C.

Sources & evidence

ORD record
ord-a0f38516ab574bf4aece3b51c8e5d7b2
Source dataset
uspto-grants-1993_03
Patent number
US05194437

Reaction notes

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