Piperidine → HCID 19759991, compound

HRID 1613856Notes

Reaction equation

HRID 1613856 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13](F)=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:17]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.CN1C(=O)CCC1>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13]([N:18]4[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]4)=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:17]=1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 13387N-methyl-2-pyrrolidoneHCID 711873HCID 711873, compound

Product 1

HCID 19759991HCID 19759991, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture containing 2.48 g (10 mmoles) of 5-chloro-2-(4-fluorophenyl)benzoxazole, 2.55 g (30 mmoles) of piperidine and 15 ml of NMP is heated with stirring under nitrogen atmosphere at 100° C. for 16 hours. The reaction is complete as judged by GC analysis. The mixture is cooled, poured into 100 ml of water and stirred for 30 minutes. The title compound (3.05 g, 97 percent yield) is filtered and washed. It has a melting point of 162° C.-164° C.

Workup

  1. temperatureis heated
  2. temperatureThe mixture is cooled
  3. stirringstirred for 30 minutes

Sources & evidence

ORD record
ord-4abf5c28a23e460db8b943266bd20d3f
Source dataset
uspto-grants-1993_03
Patent number
US05194562

Reaction notes

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