Hydrochloric Acid → Hydrochloric Acid

HRID 1614065Notes

Reaction equation

HRID 1614065 reaction equation
[I-:1].OC1C=CC=CC=1C=[N:6][C@@H:7]1[C:37](=[O:38])[N:9]2[C:10]([C:21]([O:23][CH:24]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:22])=[C:11]([CH2:14][N+:15]3[N:16]([CH3:20])[CH:17]=[CH:18][CH:19]=3)[CH2:12][S:13][C@H:8]12.[ClH:43]>O1CCCC1.C(O)C>[ClH:43].[I-:1].[NH2:6][C@@H:7]1[C:37](=[O:38])[N:9]2[C:10]([C:21]([O:23][CH:24]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[O:22])=[C:11]([CH2:14][N+:15]3[N:16]([CH3:20])[CH:17]=[CH:18][CH:19]=3)[CH2:12][S:13][C@H:8]12

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 178480369HCID 178480369, compound

Product 2

HCID 313Hydrochloric AcidHCID 178480370HCID 178480370, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of benzhydryl 7β-(2-hydroxybenzylideneamino)-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (1 g) in tetrahydrofuran (20 ml) and ethanol (3 ml) was added conc. hydrochloric acid (0.14 ml) at ambient temperature. After stirring at the same temperature for 1 hour, the mixture was poured into tetrahydrofuran (20 ml). The resulting precipitates were collected by filtration to give hydrochloric acid salt of benzhydryl 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (0.65 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-0415fabcd5ba4be1bf0ac62cd83b875d
Source dataset
uspto-grants-1993_03
Patent number
US05194432

Reaction notes

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