1,2-Dimethoxyethane → HCID 67877886, compound

HRID 1614670Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]\[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][O:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=3)[N:11]=2)[CH:5]=[CH:6][CH:7]=1.[C:29]([O:38]CC)(=O)[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33].[C:41]([O-])(=O)[CH3:42].[Na+].[CH2:46]([CH2:49]OC)OC>>[C:32]([C:31]([CH2:41][CH3:42])([CH2:46][CH3:49])[CH2:30][C:29]([NH:1][C:2]1[CH:3]=[C:4](/[CH:8]=[CH:9]\[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][O:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=3)[N:11]=2)[CH:5]=[CH:6][CH:7]=1)=[O:38])([OH:34])=[O:33]

Participants

Reactant 4

HCID 80711,2-Dimethoxyethane

HCID 31249Diethyl Succinate

HCID 517045Sodium Acetate

HCID 67877875HCID 67877875, compound

Product 1

HCID 67877886HCID 67877886, compound

Procedure

By the use of 1.7 g of 2-[(Z)-2-(3-aminophenyl)ethenyl]-6-[4-(4-methylphenyl)butoxy]methylpyridine obtained in Example 1(2), 1.1 g of anhydrous diethyl succinate, 0.75 g of sodium acetate and 10 ml of dimethoxyethane, the reaction was similarly carried out as Example 1(3). The obtained crystals was recrystallized from 50% an aqueous ethanol to give 0.86 g of 2-[(Z)-2-(3-(3-carboxy-3-ethylvalerylamino)phenyl)ethenyl]-6-[4-(4-methylphenyl)butoxy]methylpyridine, melting at 114°-116° C. as white crystals.

Workup

customThe obtained crystals was recrystallized from 50% an aqueous ethanol

Sources & evidence

ORD record: ord-9820a4b03b7240b8bb92f0b22eb329ff
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05198452

Reaction notes

Loading…