Sodium Iodide → 4-[(Trifluoroethenyl)oxy]phenol

HRID 1614678Notes

Reaction equation

HRID 1614678 reaction equation
[F:1][C:2]([O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]C)=[CH:9][CH:8]=1)=[C:3]([F:5])[F:4].C[Si](C)(C)Cl.[I-].[Na+]>C(#N)C>[F:1][C:2]([O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)=[C:3]([F:5])[F:4]

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 6397ChlorotrimethylsilaneHCID 19763912HCID 19763912, compound

Product 1

HCID 197724204-[(Trifluoroethenyl)oxy]phenol

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A sample of 4-trifluoroethenyloxyanisole prepared as in Example 2 is treated with two equivalents of trimethylchlorosilane and sodium iodide in refluxing acetonitrile to give 4-trifluoroethenyloxyphenol. The product is extracted with ether, washed with sodium thiosulfate solution to remove iodine, and then concentrated by rotary evaporation.

Sources & evidence

ORD record
ord-e3dfbbf41a5e4cd1b4a5bb76646dad24
Source dataset
uspto-grants-1993_03
Patent number
US05198513

Reaction notes

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