Formic Acid → L-Folinic acid

HRID 1614708Notes

Reaction equation

HRID 1614708 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[C:13]([OH:44])(=[O:43])[CH2:14][CH2:15][C@H:16]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]([NH:27][CH2:28][C@@H:29]2[NH:40][C:39]3[C:37](=[O:38])[NH:36][C:34]([NH2:35])=[N:33][C:32]=3[NH:31][CH2:30]2)=[CH:25][CH:24]=1)=[O:22])[C:17]([OH:19])=[O:18].C(O)=O>CN(C)C=O>[CH:1]([N:40]1[C@@H:29]([CH2:28][NH:27][C:26]2[CH:25]=[CH:24][C:23]([C:21](=[O:22])[NH:20][C@H:16]([C:17]([OH:19])=[O:18])[CH2:15][CH2:14][C:13]([OH:44])=[O:43])=[CH:42][CH:41]=2)[CH2:30][NH:31][C:32]2[N:33]=[C:34]([NH2:35])[NH:36][C:37](=[O:38])[C:39]1=2)=[O:2]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 135398650(6S)-5,6,7,8-tetrahydrofolic acid

Product 1

HCID 135398559L-Folinic acid

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The method of claim 1 wherein said treating comprises adding 1,1'-carbonyl-diimidazole to a solution of (6S)-tetrahydrofolic acid and formic acid in substantially dry N,N-dimethyl-formamide, whereby N5-Formyl-(6S)-tetrahydrofolic acid is produced.

Workup

  1. additionThe method of claim 1 wherein said treating

Sources & evidence

ORD record
ord-47dc1b82b6cc486988e81a548ccc840e
Source dataset
uspto-grants-1993_03
Patent number
US05198547

Reaction notes

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