反应详情

温度

-15 °C

3-Chloro-propionyl chloride (5.00 g) dissolved in tetrahydrofuran (50 mL) is added dropwise to a 1 M solution of allylmagnesium bromide in diethyl ether (72 mL) cooled to −15° C. The solution is warmed in the cooling bath to room temperature over a period of 2 h and stirred at room temperature overnight. Water is then added and the resulting mixture is neutralized using 4 M aqueous hydrochloric acid. The mixture is extracted with diethyl ether (3×) and the combined extracts are washed with water (2×). The organic phase is dried (Na2SO4) and the solvent is evaporated to afford the crude title compound. Yield: 7.87 g (ca. 85% pure).

1. temperatureThe solution is warmed in the cooling bath to room temperature over a period of 2 h
2. extractionThe mixture is extracted with diethyl ether (3×)
3. washthe combined extracts are washed with water (2×)
4. dry with materialThe organic phase is dried (Na2SO4)
5. customthe solvent is evaporated