反应详情

7.2 mg (0.30 mmol) lithium hydroxide were added to 75 mg (0.20 mmol) (R)-methyl 2-(3-(3,5-difluorophenyl)-1-methyl-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate in 5 ml THF and 1 ml of water. The reaction mixture was stirred for 2 h at RT and then MeOH was distilled off. The residue was made neutral with a 0.1M hydrochloric acid solution and evaporated to dryness.

1. distillationMeOH was distilled off
2. customevaporated to dryness