反应详情

温度

160 °C

6-Chloro-3-fluoro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (188 mg, 0.46 mmol) was placed in a microwave vial and dissolved in THF (4 ml). Dimethylamine (0.463 ml, 0.93 mmol) and DIPEA (0.485 ml) were added and the mixture was heated at 160° C. for 1 h under microwave irradiation. The solvent was removed in vacuo and the yellow residue was dissolved in DCM (10 ml) and washed with water (10 ml). The DCM was removed in vacuo and the solid was dried in vacuo on a high vacuum line to afford the title compound (400 mg) as a yellow solid.

1. customThe solvent was removed in vacuo
2. dissolutionthe yellow residue was dissolved in DCM (10 ml)
3. washwashed with water (10 ml)
4. customThe DCM was removed in vacuo
5. customthe solid was dried in vacuo on a high vacuum line