反应详情

温度

160 °C

To a microwave vial was added 2 ml of a solution of 6-chloro-3-fluoro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (300 mg, 0.74 mmol) in DMSO (6 ml). Piperidine (0.024 ml, 0.25 mmol) and DIPEA (0.129 ml) were added and the mixture was heated at 160° C. for 2 h under microwave irradiation. The crude reaction mixture was dissolved in DMSO/MeOH (1:1) and purified by Mass Directed Automated Preparative HPLC (Method E). The sample was further purified by Mass Directed Automated Preparative HPLC (Method E) and product-containing fractions were dried under a stream of nitrogen to afford the title compound (16 mg).

1. customThe crude reaction mixture
2. custompurified by Mass Directed Automated Preparative HPLC (Method E)
3. customThe sample was further purified by Mass Directed Automated Preparative HPLC (Method E)
4. additionproduct-containing fractions
5. customwere dried under a stream of nitrogen