Sodium hydride → HCID 178486046, compound

HRID 1616673Notes

Reaction equation

HRID 1616673 reaction equation
[H-].[Na+].[C:3]([O:7][C:8]([NH:10][C@@H:11]1[CH2:16][CH2:15][C@H:14]([C:17]([OH:19])=[O:18])[CH2:13][CH2:12]1)=[O:9])([CH3:6])([CH3:5])[CH3:4].[CH3:20]N(C)C(=O)C>>[C:3]([O:7][C:8]([N:10]([CH3:20])[C@@H:11]1[CH2:12][CH2:13][C@H:14]([C:17]([OH:19])=[O:18])[CH2:15][CH2:16]1)=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 31374DimethylacetamideHCID 178453971HCID 178453971, compound

Product 1

HCID 178486046HCID 178486046, compound

Procedure

Sodium hydride (0.22 g) is added to a solution of cis-4-tert-butoxycarbonylamino-cyclohexanecarboxylic acid (0.49 g) in N,N-dimethylacetamide (5 mL) chilled in an ice bath.

Workup

  1. temperaturechilled in an ice bath

Sources & evidence

ORD record
ord-55dd8522d1334a49adb306469d93db41
Source dataset
uspto-grants-2014_07
Patent number
US08765780B2

Reaction notes

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