P-Cresol → HCID 67402652, compound

HRID 1616953Notes

Reaction equation

HRID 1616953 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[CH:10]1[C:15]([OH:16])=[CH:14][CH:13]=[C:12]([CH3:17])[CH:11]=1.[Na:18]>C1(C)C=CC=CC=1>[Na:18].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[Na:18].[CH:14]1[C:15]([OH:16])=[CH:10][CH:11]=[C:12]([CH3:17])[CH:13]=1

Participants

6

Reactant 3

HCID 2879P-CresolHCID 90154-MethoxyphenolHCID 5360545Sodium

Product 2

HCID 67402652HCID 67402652, compoundHCID 690523411121-70-6

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

Into a 5-liter flask equipped with a reflux condenser, a thermometer, and a stirrer, 3,500 mL of toluene is weighed and put, and 770 g (6.2 mol) of 4-methoxyphenol and 670 g (6.2 mol) of p-cresol are added thereto, followed by stirring until homogeneous. 74 g (3.2 gram atom) of metallic sodium is introduced thereto at 50° C. or lower, followed by warming to 60° C. over 1 hour after the completion of the introduction, and then stirring at from 60° C. to 68° C. for 4 hours to obtain a solution of 4-methoxyphenol sodium salt and p-cresol sodium salt.

Workup

  1. customInto a 5-liter flask equipped with a reflux condenser
  2. customat 50° C.
  3. stirringstirring at from 60° C. to 68° C. for 4 hours

Sources & evidence

ORD record
ord-c2fd927d4f874496b8329c4232d252d6
Source dataset
uspto-grants-2014_07
Patent number
US08765878B2

Reaction notes

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