反应详情

温度

150 °C

Pentylamine (7.2 mL) was added to a solution of the product from step (iii) (5 g) in NMP (80 mL). The resulting solution was stirred at 150° C. for 15 h. The reaction mixture was allowed to cool, diluted with EtOAc and washed with water and brine. The organic phase was dried and evaporated under reduced pressure. The residue was suspended in diethyl ether (20 mL) and the solid was collected by filtration to give the subtitle compound as a colourless solid 1.2 g that was used without further purification.

1. temperatureto cool
2. washwashed with water and brine
3. customThe organic phase was dried
4. customevaporated under reduced pressure
5. filtrationthe solid was collected by filtration