Potassium Cyanide → HCID 178433372, compound

HRID 1617205Notes

Reaction equation

HRID 1617205 reaction equation
[C-:1]#[N:2].[K+].Cl.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]Cl)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>CN(C=O)C.CS(C)=O>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:1]#[N:2])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 178433371HCID 178433371, compound

Product 1

HCID 178433372HCID 178433372, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 6228DimethylformamideSolvent

Procedure

Potassium cyanide (2 g) was added to a solution of the product from step (ii) in DMF (20 ml) and DMSO (10 ml) and the mixture stirred at rt for 18 h. The mixture was flushed with nitrogen for 20 min, then diluted with brine (80 ml), stirred for 10 min and the precipitate filtered, washed with water then ether and dried to afford the subtitle compound, 2.46 g.

Workup

  1. customThe mixture was flushed with nitrogen for 20 min
  2. additiondiluted with brine (80 ml)
  3. stirringstirred for 10 min
  4. filtrationthe precipitate filtered
  5. washwashed with water
  6. dry with materialether and dried

Sources & evidence

ORD record
ord-2ea4a16d71b64e6e97ad915f5099e11a
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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