反应详情

温度

80 °C

NBS (2.72 g) and AIBN (0.136 g) were added in one portion to a solution of 2-(4-methoxy-3-methylphenyl)acetic acid (2.99 g) in EtOAc (50 ml) and stirred at 80° C. for 2 h. Another portion of AIBN (0.136 g) was added and the suspension stirred for a further 2 h. The reaction mixture was diluted with EtOAc, washed with sat. sodium thiosulfate solution, 2M HCl, water, and sat. brine. The organic phase was dried, filtered and evaporated to afford the subtitle compound, 4.10 g.

1. stirringthe suspension stirred for a further 2 h
2. washwashed with sat. sodium thiosulfate solution, 2M HCl, water, and sat. brine
3. customThe organic phase was dried
4. filtrationfiltered
5. customevaporated