Hydrochloric Acid → HCID 67391110, compound

HRID 1617348Notes

Reaction equation

HRID 1617348 reaction equation
[C:1]([CH2:3][C:4]1([N:23]2[CH:27]=[C:26]([C:28]3[C:29]4[CH:36]=[CH:35][N:34]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:44])([CH3:43])[CH3:42])[C:30]=4[N:31]=[CH:32][N:33]=3)[CH:25]=[N:24]2)[CH2:7][N:6]([CH:8]2[CH2:14][CH:13]3[N:15](C(OC(C)(C)C)=O)[CH:10]([CH2:11][CH2:12]3)[CH2:9]2)[CH2:5]1)#[N:2].[ClH:45]>C1COCC1.O1CCOCC1>[ClH:45].[ClH:45].[ClH:45].[CH:13]12[NH:15][CH:10]([CH2:11][CH2:12]1)[CH2:9][CH:8]([N:6]1[CH2:5][C:4]([CH2:3][C:1]#[N:2])([N:23]3[CH:27]=[C:26]([C:28]4[C:29]5[CH:36]=[CH:35][N:34]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:42])([CH3:44])[CH3:43])[C:30]=5[N:31]=[CH:32][N:33]=4)[CH:25]=[N:24]3)[CH2:7]1)[CH2:14]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67390268HCID 67390268, compound

Product 1

HCID 67391110HCID 67391110, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 3-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}-8-azabicyclo[3.2.1]octane-8-carboxylate (123 mg, 0.2 mmol) in THF (3 mL) was added a 4 N solution of HCl in dioxane (3 mL). After being stirred at room temperature for 2 hours, the solution was concentrated. The residue obtained was used for the next reaction. LC-MS: 519.3 (M+H)+.

Workup

  1. concentrationthe solution was concentrated
  2. customThe residue obtained
  3. customwas used for the next reaction

Sources & evidence

ORD record
ord-43305b43d8cb4c51abbbfd5f05d35c1e
Source dataset
uspto-grants-2014_07
Patent number
US08765734B2

Reaction notes

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