反应详情

A solution of methylamine (33 wt % in Ethanol, 1.12 mmol, Aldrich) was added portionwise to a solution of ethyl 6-(bromomethyl)-2-(trifluoromethyl)pyrimidine-4-carboxylate (0.150 g, 0.321 mmol, Example 5, Step A) in methylene chloride (3.0 mL), until reaction was complete. Solvent was removed in vacuo. The residue was dissolved in tetrahydrofuran (7.0 mL) and water (2.0 mL), and lithium hydroxide monohydrate (0.135 g, 3.21 mmol) was added. After a 5 minute reaction time, the mixture was treated with 1N HCl to adjust the pH to 7, then was purified using preparative HPLC-MS (C18 eluting with a gradient of MeCN/H2O containing 0.15% NH4OH). LC-MS: 236.1 (M+H)+.

1. customSolvent was removed in vacuo
2. dissolutionThe residue was dissolved in tetrahydrofuran (7.0 mL)
3. customAfter a 5 minute reaction time
4. customwas purified
5. washeluting with a gradient of MeCN/H2O containing 0.15% NH4OH)