Hydroxyamine hydrochloride → HCID 136359960, compound

HRID 1617442Notes

Reaction equation

HRID 1617442 reaction equation
[CH3:1][N:2]([CH3:26])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=O)=[CH:5][CH:4]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[CH3:1][N:2]([CH3:26])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:28][OH:29])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015545HCID 67015545, compound

Product 1

HCID 136359960HCID 136359960, compound

Procedure

In analogy to example 1, step 2, from 3-(4-dimethylamino-phenyl)-1-pyridin-4-yl-3-m-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (3:1) as a yellow foam, MS (ESI+): m/z=360.1 ([M+H]+).

Sources & evidence

ORD record
ord-df3870e31bf24f5b875ff9756cd275e1
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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