Hydroxyamine hydrochloride → HCID 58043533, compound

HRID 1617474Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH2:9][C:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[C:13]=2[F:20])=O)=[CH:4][CH:3]=1.Cl.[NH2:29][OH:30].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH2:9]/[C:10](/[C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[C:13]=2[F:20])=[N:29]\[OH:30])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 66669181HCID 66669181, compound

Product 1

HCID 58043533HCID 58043533, compound

Procedure

In analogy to example 1, step 2, from 3-(4-bromo-phenyl)-3-o-tolyl-1-(2,3,5-trifluoro-phenyl)-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a white foam, MS (ESI−): m/z=446.0 ([M−H]−, 1Br).

Sources & evidence

ORD record: ord-b46612f86d4b4bf9baf2f4b3e52e780e
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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