Hydroxyamine hydrochloride → (NE)-N-[1-(2-fluoro-6-methyl-4-pyridinyl)-3,3-diphenylpropylidene]hydroxylamine

HRID 1617482Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[C:4]([CH3:24])[N:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[F:1][C:2]1[CH:7]=[C:6](/[C:8](=[N:26]/[OH:27])/[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[C:4]([CH3:24])[N:3]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 666663611-(2-Fluoro-6-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one

Product 1

HCID 136166973(NE)-N-[1-(2-fluoro-6-methyl-4-pyridinyl)-3,3-diphenylpropylidene]hydroxylamine

Procedure

In analogy to example 1, step 2, from 1-(2-fluoro-6-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a white oil, MS (ESI+): m/z=335.1553 ([M+H]+).

Sources & evidence

ORD record: ord-cfcc1cb3afcd4c26934f214372370fee
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

Loading…