Hydroxyamine hydrochloride → HCID 136359978, compound

HRID 1617493Notes

Reaction equation

[CH3:1][N:2]([CH3:28])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=O)=[CH:5][CH:4]=1.Cl.[NH2:30][OH:31].C([O-])(O)=O.[Na+]>>[CH3:1][N:2]([CH3:28])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:30][OH:31])=[CH:5][CH:4]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 66668312HCID 66668312, compound

Product 1

HCID 136359978HCID 136359978, compound

Procedure

In analogy to example 1, step 2, from 3-(4-dimethylamino-phenyl)-3-(1H-indol-3-yl)-1-pyridin-4-yl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.8:1) as a yellow foam, MS (ESI+): m/z=385.4 ([M+H]+).

Sources & evidence

ORD record: ord-deb558b499c048e984e33b9cb06738f8
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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