Hydroxyamine hydrochloride → HCID 136260512, compound

HRID 1617495Notes

Reaction equation

HRID 1617495 reaction equation
[CH3:1][N:2]([CH3:25])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:10][C:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=O)=[CH:5][CH:4]=1.Cl.[NH2:27][OH:28].C([O-])(O)=O.[Na+]>>[CH3:1][N:2]([CH3:25])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:10]/[C:11](/[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:27]\[OH:28])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666439HCID 66666439, compound

Product 1

HCID 136260512HCID 136260512, compound

Procedure

In analogy to example 1, step 2, from 3-(4-dimethylamino-phenyl)-3-pyridin-2-yl-1-pyridin-4-yl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a yellow foam, MS (ESI+): m/z=347.2 ([M+H]+).

Sources & evidence

ORD record
ord-9cd2ee8f48a946e5ad7fef2424e01801
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…