Hydroxyamine hydrochloride → HCID 136167072, compound

HRID 1617498Notes

Reaction equation

HRID 1617498 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:5]=[C:4]([CH3:24])[N:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[CH3:1][C:2]1[CH:7]=[C:6](/[C:8](=[N:26]/[OH:27])/[CH2:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:5]=[C:4]([CH3:24])[N:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666154HCID 66666154, compound

Product 1

HCID 136167072HCID 136167072, compound

Procedure

In analogy to example 1, step 2, from 1-(2,6-dimethyl-pyridin-4-yl)-3-phenyl-3-pyridin-2-yl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a light yellow foam, MS (ESI+): m/z=332.3 ([M+H]+).

Sources & evidence

ORD record
ord-6d1831c5e9c64087b64d95d89614a38a
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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