反应详情

Cs2CO3 (4 g, 12.3 mmol) was added to a solution of phenol (1 g, 10.6 mmol) in 50 mL of THF under N2 atmosphere. After stirring for 15 min. 1,4-dibromo-2-nitrobenzene (2.81 g, 10 mmol) was added. The resulting mixture was heated to reflux and stirred overnight at reflux. Water and ethyl acetate were added, followed by extraction with ethyl acetate (3×). The combined organic layers were washed with water and brine, dried (Na2SO4) and evaporated to give the crude compound (3.2 g, 75%).

1. temperatureThe resulting mixture was heated
2. temperatureto reflux
3. stirringstirred overnight
4. temperatureat reflux
5. extractionfollowed by extraction with ethyl acetate (3×)
6. washThe combined organic layers were washed with water and brine
7. dry with materialdried (Na2SO4)
8. customevaporated