Hydroxyamine hydrochloride → HCID 136360005, compound

HRID 1617551Notes

Reaction equation

HRID 1617551 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[N:28][OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015529HCID 67015529, compound

Product 1

HCID 136360005HCID 136360005, compound

Procedure

In analogy to example 74, step 7, from 3-(4-bromo-phenyl)-1-(2-methoxy-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (2.7:1) as a white foam, MS (ESI+): m/z=425.1 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-8c89738650a147339dc90c8cdb2e049a
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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