反应详情

In analogy to example 74, step 7, from 3-(4-bromo-phenyl)-1-(5-chloro-2-fluoro-pyridin-4-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (1.6:1) as a white foam, MS (ESI−): m/z=445.0124 ([M−H]−, 1Br).