Hydroxyamine hydrochloride → HCID 58043610, compound

HRID 1617578Notes

Reaction equation

HRID 1617578 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[C:13]([F:19])=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9]/[C:10](/[C:12]2[C:13]([F:19])=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=2)=[N:28]\[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015626HCID 67015626, compound

Product 1

HCID 58043610HCID 58043610, compound

Procedure

In analogy to example 74, step 7, from 3-(4-bromo-phenyl)-1-(2-fluoro-5-methyl-pyridin-3-yl)-3-o-tolyl-propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a colorless oil, MS (ESI+): m/z=427.0814 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-63f4a11256b64673a9a368cf9b1e0369
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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