Hydroxyamine hydrochloride → HCID 136360016, compound

HRID 1617581Notes

Reaction equation

HRID 1617581 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([OH:32])=[O:31])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[C:5]([CH3:34])=[CH:4][N:3]=1.Cl.[NH2:36][OH:37].C([O-])(O)=O.[Na+]>>[F:1][C:2]1[CH:7]=[C:6]([C:8](=[N:36][OH:37])[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:25]=[CH:26][C:27]([C:30]([OH:32])=[O:31])=[CH:28][CH:29]=3)=[CH:20][CH:19]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[C:5]([CH3:34])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015633HCID 67015633, compound

Product 1

HCID 136360016HCID 136360016, compound

Procedure

In analogy to example 74, step 7, from 4′-[3-(2-fluoro-5-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as a mixture of E and Z isomers (1.7:1) as a colorless oil, MS (ESI+): m/z=469.1924 ([M+H]+).

Sources & evidence

ORD record
ord-621d70dc6daa4df390e30e4eeb8635c8
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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