Hydroxyamine hydrochloride → HCID 136166897, compound

HRID 1617598Notes

Reaction equation

HRID 1617598 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=2[CH3:26])[CH2:9]/[C:10](/[C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[N:28]\[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66666534HCID 66666534, compound

Product 1

HCID 136166897HCID 136166897, compound

Procedure

In analogy to example 74, step 7, from 3-(4-bromophenyl)-3-(4-fluoro-2-methylphenyl)-1-(2-methylpyridin-4-yl)propan-1-one and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound which contains less than 10% of the Z isomer as a white foam, MS (ESI+): m/z=427.08 [M+H]+.

Sources & evidence

ORD record
ord-04c138d090074763beea6498201c61bf
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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