Hydroxyamine hydrochloride → HCID 136167020, compound

HRID 1617622Notes

Reaction equation

HRID 1617622 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9][C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH2:9]/[C:10](/[C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=[N:26]\[OH:27])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015540HCID 67015540, compound

Product 1

HCID 136167020HCID 136167020, compound

Procedure

In analogy to example 151, step 3, 3-(4-bromo-phenyl)-1-pyrazin-2-yl-3-o-tolyl-propan-1-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing about 10% of the corresponding Z isomer as a colorless foam, MS (ESI−): m/z=393.8 [M−H]−.

Sources & evidence

ORD record
ord-a40fa3296d0e4835bce569a2309f23cc
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…