Hydroxyamine hydrochloride → HCID 136166853, compound

HRID 1617627Notes

Reaction equation

HRID 1617627 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH2:15][C:16]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH2:15]/[C:16](/[C:18]3[CH:23]=[CH:22][N:21]=[C:20]([CH3:24])[CH:19]=3)=[N:26]\[OH:27])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015629HCID 67015629, compound

Product 1

HCID 136166853HCID 136166853, compound

Procedure

In analogy to example 151, step 3, 2-[1-(4-methoxy-phenyl)-cyclohexyl]-1-(2-methyl-pyridin-4-yl)-ethanone was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=339.3 [M+H]+.

Sources & evidence

ORD record
ord-deb50aa12eb44b5a900efaf5671b2ef4
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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