Hydroxyamine hydrochloride → HCID 136166944, compound

HRID 1617630Notes

Reaction equation

HRID 1617630 reaction equation
[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:8][C:9]([C:11]2[CH:12]=[CH:13][C:14](=[O:17])[NH:15][CH:16]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:25][OH:26].C([O-])(O)=O.[Na+]>>[OH:26]/[N:25]=[C:9](/[C:11]1[CH:12]=[CH:13][C:14](=[O:17])[NH:15][CH:16]=1)\[CH2:8][CH:7]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668615HCID 66668615, compound

Product 1

HCID 136166944HCID 136166944, compound

Procedure

In analogy to example 151, step 3, 5-(3,3-diphenyl-propionyl)-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing less than 10% of the corresponding Z isomer as a colorless solid, MS (ESI−): m/z=317.1 [M−H]−.

Sources & evidence

ORD record
ord-a23e428132bc4300a71c01ff6b2f6e57
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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