Hydroxyamine hydrochloride → HCID 58043163, compound

HRID 1617632Notes

Reaction equation

HRID 1617632 reaction equation
[C:1]1([CH:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:8][C:9]([C:11]2[CH:12]=[CH:13][C:14](=[O:18])[N:15]([CH3:17])[CH:16]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[OH:27]/[N:26]=[C:9](/[C:11]1[CH:12]=[CH:13][C:14](=[O:18])[N:15]([CH3:17])[CH:16]=1)\[CH2:8][CH:7]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668631HCID 66668631, compound

Product 1

HCID 58043163HCID 58043163, compound

Procedure

In analogy to example 151, step 3, 5-(3,3-diphenyl-propionyl)-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing less than 10% of the corresponding Z isomer as a colorless solid, MS (ESI+): m/z=333.3 [M+H]+.

Sources & evidence

ORD record
ord-a413b5b2f7444cf497a133b9f276a773
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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