Hydroxyamine hydrochloride → HCID 58043548, compound

HRID 1617657Notes

Reaction equation

HRID 1617657 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH:21]=[CH2:22])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:24][OH:25].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH:21]=[CH2:22])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:24]\[OH:25])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015578HCID 67015578, compound

Product 1

HCID 58043548HCID 58043548, compound

Procedure

In analogy to example 151, step 3, 5-[3-(4-bromo-phenyl)-hex-5-enoyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI−): m/z=373.1 [M−H]−.

Sources & evidence

ORD record
ord-4fdac9adf8614e218f00dd20253ab2b3
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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