Hydroxyamine hydrochloride → HCID 58043400, compound

HRID 1617660Notes

Reaction equation

HRID 1617660 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:25][OH:26].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:25]\[OH:26])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015610HCID 67015610, compound

Product 1

HCID 58043400HCID 58043400, compound

Procedure

In analogy to example 151, step 3, 5-[3-(4-bromo-phenyl)-heptanoyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing 4% of the corresponding Z isomer as a colorless foam, MS (ESI+): m/z=391.3 [M+H]+.

Sources & evidence

ORD record
ord-a3f3b5d6b96e46cba83f896140944429
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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