Hydroxyamine hydrochloride → HCID 58043381, compound

HRID 1617666Notes

Reaction equation

HRID 1617666 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:20]2[CH2:23][CH2:22][CH2:21]2)[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:25][OH:26].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:20]2[CH2:23][CH2:22][CH2:21]2)[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:25]\[OH:26])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66669280HCID 66669280, compound

Product 1

HCID 58043381HCID 58043381, compound

Procedure

In analogy to example 151, step 3, 5-[3-(4-bromo-phenyl)-3-cyclobutyl-propionyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=389.1 [M+H]+.

Sources & evidence

ORD record
ord-0acf2a41eb6247e0b5f0aae465e1e56c
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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