Hydroxyamine hydrochloride → HCID 58043291, compound

HRID 1617676Notes

Reaction equation

HRID 1617676 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:23])[N:16]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:32][OH:33].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:23])[N:16]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH:17]=2)=[N:32]\[OH:33])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 67015663HCID 67015663, compound

Product 1

HCID 58043291HCID 58043291, compound

Procedure

In analogy to example 151, step 3, 3-{5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-2-oxo-2H-pyridin-1-yl}-propionic acid was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI−): m/z=481.0 [M−H]−.

Sources & evidence

ORD record
ord-1360e27d7fd4415184fd7e8138e23cf1
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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