Potassium Carbonate → HCID 67015585, compound

HRID 1617677Notes

Reaction equation

HRID 1617677 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[O:11])=[CH:4][CH:3]=1.[CH3:27][O:28][C:29](=[O:34])[CH2:30][CH2:31]CBr.C(=O)([O-])[O-].[K+].[K+]>>[CH3:27][O:28][C:29](=[O:34])[CH2:30][CH2:31][CH2:18][N:16]1[CH:17]=[C:12]([C:10](=[O:11])[CH2:9][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH:13]=[CH:14][C:15]1=[O:19]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 107604Methyl 4-bromobutyrateHCID 666685075-[3-(4-Bromo-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Product 1

HCID 67015585HCID 67015585, compound

Procedure

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one (example 162, step 3) was reacted with methyl-4-bromobutyrate in the presence of potassium carbonate to give the title compound as a colorless foam, MS (ESI+): m/z=496.2 [M+H]+.

Sources & evidence

ORD record
ord-99063b58a27e493cbac1912ac168d582
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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