Hydroxyamine hydrochloride → HCID 58043419, compound

HRID 1617678Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:24])[N:16]([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:33][OH:34].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[CH3:31])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:24])[N:16]([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:17]=2)=[N:33]\[OH:34])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 66668797HCID 66668797, compound

Product 1

HCID 58043419HCID 58043419, compound

Procedure

In analogy to example 151, step 3, 4-{5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-2-oxo-2H-pyridin-1-yl}-butyric acid was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI−): m/z=495.1 [M−H]−.

Sources & evidence

ORD record: ord-6c8bdcaf67aa4acf9b8fd254e8b3c349
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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