Hydroxyamine hydrochloride → HCID 58043445, compound

HRID 1617692Notes

Reaction equation

HRID 1617692 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)[CH2:9][C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)=O.Cl.[NH2:26][OH:27].C([O-])(O)=O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)[CH2:9]/[C:10](/[C:12]1[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=1)=[N:26]\[OH:27]

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66668978HCID 66668978, compound

Product 1

HCID 58043445HCID 58043445, compound

Procedure

In analogy to example 151, step 3, 5-[3-(2-chloro-phenyl)-3-cyclopentyl-propionyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI+): m/z=359.2 [M+H]+.

Sources & evidence

ORD record
ord-58f7a9b0ef3b4841befd8b37fe9e1165
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…