Methyl iodide → HCID 66669196, compound

HRID 1617700Notes

Reaction equation

HRID 1617700 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.IC.[C:28](=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH3:28])[CH:17]=2)=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66669220HCID 66669220, compound

Product 1

HCID 66669196HCID 66669196, compound

Procedure

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-3-(2-chloro-phenyl)-propionyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a colorless solid, MS (ESI−): m/z=429.9 [M−H]−.

Sources & evidence

ORD record
ord-4d58f2a399ff46f9a0bd58a413f23b73
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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