Hydroxyamine hydrochloride → HCID 58043463, compound

HRID 1617714Notes

Reaction equation

[CH3:1][N:2]([CH2:30][C:31]([OH:33])=[O:32])[C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH3:21])[CH:15]=2)=O)=[CH:6][CH:5]=1.Cl.[NH2:35][OH:36].C([O-])(O)=O.[Na+]>>[OH:36]/[N:35]=[C:12](/[C:14]1[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH3:21])[CH:15]=1)\[CH2:11][CH:10]([C:7]1[CH:8]=[CH:9][C:4]([C:3]([N:2]([CH2:30][C:31]([OH:33])=[O:32])[CH3:1])=[O:29])=[CH:5][CH:6]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH3:28]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

HCID 67015686HCID 67015686, compound

Product 1

HCID 58043463HCID 58043463, compound

Procedure

In analogy to example 151, step 3, (methyl-{4-[3-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3-oxo-1-o-tolyl-propyl]-benzoyl}-amino)-acetic acid was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless solid, MS (ESI−): m/z=460.3 [M−H]−.

Sources & evidence

ORD record: ord-59f03d20e3604472886a10c7ad4eb804
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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