Hydrochloric Acid → HCID 66666103, compound

HRID 1617721Notes

Reaction equation

HRID 1617721 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([F:30])[CH:21]=1)[CH2:9][C:10]([C:12]1[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=1)=[O:11].Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([F:30])[CH:21]=1)[CH2:9][C:10](=[O:11])[C:12]1[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66666666HCID 66666666, compound

Product 1

HCID 66666103HCID 66666103, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, methyl 4-(1-(2-chlorophenyl)-3-(6-methoxypyridin-3-yl)-3-oxopropyl)-2-fluorobenzoate was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colorless foam, MS (ESI+): m/z=414.2 [M+H]+.

Sources & evidence

ORD record
ord-254b32ee64c446129719929f31e0a8cb
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…