HRID1617727

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID443297

未命名化合物

HCID516892

Sodium Bicarbonate

CHNaO3

结构：CN1CCC(N(C)C(=O)c2ccc(C(CC(=O)c3ccc(=O)n(C)c3)c3ccccc3Cl)cc2F)CC1

HCID67015573

未命名化合物

PRODUCTS

生成物

$结构：CN1CCC(N(C)C(=O)c2ccc(C(C/C(=N\O)c3ccc(=O)n(C)c3)c3ccccc3Cl)cc2F)CC1$

HCID58043171

未命名化合物

PROCEDURE

实验过程

In analogy to example 151, step 3, 4-(1-(2-chlorophenyl)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxopropyl)-2-fluoro-N-methyl-N-(1-methylpiperidin-4-yl)benzamide was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound containing 10% of the corresponding Z isomer as a colorless foam, MS (ESI+): m/z=539.3 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b3856ad93d646df961cd7ff035419f5
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08765730B2
来源说明: uspto-grants-2014_07

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:36]=[CH:35][C:23]([C:24]([N:26]([CH3:34])[CH:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[O:25])=[C:22]([F:37])[CH:21]=1)[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=1)=O.Cl.[NH2:39][OH:40].C([O-])(O)=O.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:20]1[CH:36]=[CH:35][C:23]([C:24]([N:26]([CH3:34])[CH:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[O:25])=[C:22]([F:37])[CH:21]=1)[CH2:9]/[C:10](=[N:39]\[OH:40])/[C:12]1[CH:17]=[CH:16][C:15](=[O:18])[N:14]([CH3:19])[CH:13]=1