Methyl iodide → HCID 66668646, compound

HRID 1617732Notes

Reaction equation

HRID 1617732 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH3:27])[CH2:11][C:12]([C:14]1[CH:15]=[CH:16][C:17](=[O:20])[NH:18][CH:19]=1)=[O:13].IC.[C:30](=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[CH:10]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH3:27])[CH2:11][C:12]([C:14]1[CH:15]=[CH:16][C:17](=[O:20])[N:18]([CH3:30])[CH:19]=1)=[O:13]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66669269HCID 66669269, compound

Product 1

HCID 66668646HCID 66668646, compound

Procedure

In analogy to example 161, step 1, 5-[3-(2-fluoro-4-methoxy-phenyl)-3-o-tolyl-propionyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a colorless solid, MS (ESI+): m/z=380.3 [M+H]+.

Sources & evidence

ORD record
ord-a246245b11314e9b8e8edf0f9271f472
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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