Hydroxyamine hydrochloride → HCID 58043617, compound

HRID 1617768Notes

Reaction equation

HRID 1617768 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=O)=[CH:4][CH:3]=1.Cl.[NH2:28][OH:29].C([O-])(O)=O.[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])[CH2:9]/[C:10](/[C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[N:28]\[OH:29])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 66669163HCID 66669163, compound

Product 1

HCID 58043617HCID 58043617, compound

Procedure

In analogy to example 151, step 3, 5-[3-(4-bromo-phenyl)-3-(2-fluoro-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of NaHCO3 to give the title compound as a colorless foam, MS (ESI+): m/z=429.0 [M+H]+.

Sources & evidence

ORD record
ord-be1779a2a3d647049df3e00a0fd9b043
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

Loading…